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In terms of kidney function, while the initial eGFR for GLP-1 RAs users was notably lower, the difference was no longer significant by the D60-90 interval, hinting at a possible stabilization or amelioration in kidney function attributed to GLP-1 RAs therapy (Figure S2)

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Given the interconnectedness of de novo serine synthesis with glycolysis and gluconeogenesis pathways, this study tested the hypothesis that hepatic PSAT1 is needed for the liver glucose and lipid adaptations to SAAR

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